BS in Biochemistry, Universidad Complutense, Madrid, 1980
PhD in Biochemistry and Molecular Biology, Universidad Complutense, Madrid, 1984
Interest:
Molecular and cellular events underlying asthma, cancer and obesity
Recent Awards/Honors:
1995: Elected member of the European Molecular Biology Organization (EMBO) 1998: Award of the Foundation for Health Sciences 1999: Award of the Spanish Royal Academy of Sciences 2000: Award of the Carmen and Severo Ochoa Foundation 2001: Award of the Juan March Foundation 2002: Member of the Editorial Board of EMBO Journal 2002: Member of the Editorial Board of EMBO Reports 2006: Elected Member of the Academia Europaea
Selected Publications:
Berra, E., Diaz-Meco, M.T., Dominguez, I., Municio, M.M., Sanz, L., Lozano, J., Chapkin, R.S., Moscat, J. (1993). Protein kinase C z Isoform is Critical for Mitogenic Signal Transduction. Cell 74, 555-563
Diaz-Meco, M.T., Municio, M.M., Frutos, S., Sanchez, P., Lozano, J., Sanz, L., Moscat, J. (1996). The Product of par-4, a Gene Induced During Apoptosis, Interacts Selectively with the Atypical Isoforms of Protein Kinase C. Cell 86, 777-786
Barradas, M., Monjas, A., Diaz-Meco, M.T., Serrano, M., Moscat, J. (1999). The Down-regulation of the Pro-apoptotic Protein Par-4 is Critical for Ras-Induced Survival and Tumor Progression. EMBO J. 18, 6362-6369
Sanz, L., Diaz-Meco, M.T., Nakano, H., Moscat, J. (2000) The atypical PKC- interacting protein p62 channels NF-kB activation by the IL-1/TRAF6 pathway. EMBO J. 19, 1576-1586
Leitges, M., Sanz, L., Martin, P., Duran, A., Braum, U., Garcia, J.F., Camacho, F., Diaz-Meco, M.T., Rennert, P.D., Moscat, J. (2001) Targeted disruption of the zPKC gene results in the impairment of the NF-kB pathway. Mol. Cell 8, 771-780
Duran, A., Serrano, M., Leitges, M., Flores, J.M., Picard, S., Brown, J.P., Moscat, J., Diaz-Meco, M.T. (2004) The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Dev. Cell 6, 303-309
Rodriguez, A., Durán, A., Selloum, M., Champy, M.F., Diez-Guerra, F.J., Flores, J.M., Serrano, M., Auwerx, J., Diaz-Meco, M.T., and Moscat, J. (2006) Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62. Cell Metab. 3, 211-222
Moscat, J., Diaz-Meco, M.T., Albert, A., Campuzano, S. (2006) Cell signalling and function organized by PB1 domain interactions. (Review) Mol. Cell 23, 631-640
The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis.Duran A, Linares JF, Galvez AS, Wikenheiser K, Flores JM, Diaz-Meco MT, Moscat J. Cancer Cell. 2008 Apr;13(4):343-54.
P62 at the crossroads of autophagy, apoptosis, and cancer. Moscat J, Diaz-Meco MT.Cell. 2009 Jun 12;137(6):1001-4. Review.
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